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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60539 | KG-548 | ||
KG-548 是一种ARNT/TACC3干扰剂以及HIF-1α抑制剂。KG-548 通过 ARNT 的 PAS-B 结构域与 TACC3 竞争性结合,直接干扰ARNT/TACC3复合物的形成。ARNT 是芳基烃受体核转运蛋白,也称为 HIF-β。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00957 |
ARNT Protein, Human, Recombinant (His)
Hypoxia-inducible factor 1-beta,Class E basic helix-loop-hel... |
Human | P. pastoris (Yeast) |
ARNT Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPY-01709 |
HIF-1 alpha Protein, Human, Recombinant (His)
bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b... |
Human | E. coli |
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has... |